Lange, Klaus W. and Tucha, O. and Alders, G. L. and Preier, M. and Csoti, I. and Merz, B. and Mark, G. and Herting, B. and Fornadi, F. and Reichmann, H. and Vieregge, P. and Reiners, K. and Becker, G. and Naumann, M. (2003) Differentiation of parkinsonian syndromes according to differences in executive functions. JOURNAL OF NEURAL TRANSMISSION, 110 (9). pp. 983-995. ISSN 0300-9564, 1435-1463
Full text not available from this repository. (Request a copy)Abstract
Groups of patients with Parkinson's disease (PD), striatonigral degeneration-type multiple system atrophy (MSA) or progressive supranuclear palsy (PSP) with motor disability stages II and III according to Hoehn and Yahr, and a healthy control group were compared using neuropsychological tests of executive functions. The results indicate that all three patient groups were impaired in the tests of executive functions. In comparison with healthy subjects, the three patient groups showed impaired performance regarding verbal fluency, problem solving and verbal and figural working memory. Patients with PD differed significantly from healthy subjects in a test of verbal recency, while patients with MSA or PSP were unimpaired. The comparison of patient groups revealed no differences between PD and MSA patients. However, patients with PSP showed greater impairment in both phonemic and semantic fluency than patients with PD or MSA. Using discriminant function analysis, it was found that variables derived from four verbal fluency tasks (simple and alternate semantic and phonemic fluency) discriminated among the three patient groups at a level significantly exceeding chance. Over 90% of patients with PSP were correctly classified. Patients with PD and MSA were correctly classified in over 70% of cases. These results suggest that verbal fluency tasks may be sensitive measures in the differential diagnosis of PD, MSA and PSP.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROGRESSIVE SUPRANUCLEAR PALSY; FRONTAL-LOBE DYSFUNCTION; MULTIPLE SYSTEM ATROPHY; RICHARDSON-OLSZEWSKI-SYNDROME; COGNITIVE IMPAIRMENT; SUBCORTICAL DEMENTIA; ALZHEIMERS-DISEASE; STRIATONIGRAL DEGENERATION; HUNTINGTONS-DISEASE; VISUOSPATIAL MEMORY; Parkinson's disease; multiple system atrophy; progressive supranuclear palsy; executive functions; neuropsychology; differential diagnosis |
| Subjects: | 100 Philosophy & psychology > 150 Psychology |
| Divisions: | Human Sciences > Institut für Psychologie > Lehrstuhl für Psychologie III (Biologische, Klinische und Rehabilitationspsychologie) - Prof. Dr. Klaus W. Lange |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Sep 2021 12:37 |
| Last Modified: | 01 Sep 2021 12:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38670 |
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