Edinger, Matthias and Hoffmann, Petra and Ermann, Joerg and Drago, Kathryn and Fathman, C Garrison and Strober, Samuel and Negrin, Robert S. (2003) CD4(+)CD25(+) regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. NATURE MEDICINE, 9 (9). pp. 1144-1150. ISSN 1078-8956
Full text not available from this repository.Abstract
Mature donor T cells cause graft-versus-host disease (GVHD), but they are also the main mediators of the beneficial graft-versus-tumor (GVT) activity of allogeneic bone marrow transplantation. Suppression of GVHD with maintenance of GVT activity is a desirable outcome for clinical transplantation. We have previously shown that donor-derived CD4(+)CD25(+) regulatory T cells inhibit lethal GVHD after allogeneic bone marrow transplantation across major histocompatibility complex (MHC) class I and II barriers in mice. Here we demonstrate that in host mice with leukemia and lymphoma, CD4(+)CD25(+) regulatory T cells suppress the early expansion of alloreactive donor T cells, their interleukin-2-receptor (IL-2R) alpha-chain expression and their capacity to induce GVHD without abrogating their GVT effector function, mediated primarily by the perforin lysis pathway. Thus, CD4(+)CD25(+) T cells are potent regulatory cells that can separate GVHD from GVT activity mediated by conventional donor T cells.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHRONIC MYELOGENOUS LEUKEMIA; IN-VIVO; ACTIVATION; DEPLETION; INDUCTION; PHENOTYPE; MECHANISM; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Jul 2021 11:13 |
| Last Modified: | 29 Jul 2021 11:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38679 |
Actions (login required)
 |
View Item |
