Meyer, Martin and Neff, Patrick and Liem, Franziskus and Kleinjung, Tobias and Weidt, Steffi and Langguth, Berthold and Schecklmann, Martin (2016) Differential tinnitus-related neuroplastic alterations of cortical thickness and surface area. HEARING RESEARCH, 342. pp. 1-12. ISSN 0378-5955, 1878-5891
Full text not available from this repository. (Request a copy)Abstract
Structural neuroimaging techniques have been used to identify cortical and subcortical regions constituting the neuroarchitecture of tinnitus. One recent investigation used voxel-based morphometry (VBM) to analyze a sample of tinnitus patients (Tl, n = 257) (Schecklmann et al., 2013). A negative relationship between individual distress and cortical volume (CV) in bilateral auditory regions was observed. However, CV has meanwhile been identified as a neuroanatomical measurement that confounds genetically distinct neuroanatomical traits, namely cortical thickness (CT) and cortical surface area (CSA). We performed a re-analysis of the identical sample using the automated FreeSurfer surface-based morphometry (SBM) approach (Fischl, 2012). First, we replicated the negative correlation between tinnitus distress and bilateral supratemporal gray matter volume. Second, we observed a negative correlation for CSA in the left periauditory cortex and anterior insula. Furthermore, we noted a positive correlation between tinnitus duration and CT in the left periauditory cortex as well as a negative correlation in the subcallosal anterior cingulate, a region collated to the serotonergic circuit and germane to inhibitory functions. In short, the results elucidate differential neuroanatomical alterations of CSA and CT for the two independent tinnitus-related psychological traits distress and duration. Beyond this, the study provides further evidence for the distinction and specific susceptibility of CSA and CT within the context of neuroplasticity of the human brain. (C) 2016 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN CEREBRAL-CORTEX; VOXEL-BASED MORPHOMETRY; INSULAR CORTEX; HUMAN BRAIN; STRUCTURAL ASYMMETRY; AUDITORY-PERCEPTION; COORDINATE SYSTEM; ANTERIOR INSULA; HEARING-LOSS; GRAY-MATTER; Tinnitus; Surface-based morphometry; Neuroanatomy; Cortical thickness; Cortical surface area |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Apr 2019 11:09 |
| Last Modified: | 10 Apr 2019 11:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3872 |
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