Bosserhoff, Anja K. and Buettner, Reinhard (2003) Establishing the protein MIA (melanoma inhibitory activity) as a marker for chondrocyte differentiation. BIOMATERIALS, 24 (19). pp. 3229-3234. ISSN 0142-9612
Full text not available from this repository.Abstract
Melanoma inhibitory activity (MIA), also referred to as cartilage derived retinoic acid-sensitive protein (CD-RAP), is detected physiologically in cartilage tissue and pathologically in malignant melanomas. To measure MIA/CD-RAP quantitatively we developed a sensitive ELISA system. Recently, we described diagnostic applications of the MIA-ELISA in patients with cartilage diseases. The study described herein was performed to determine whether there is any relation between MIA/CD-RAP levels and the degree of chondrocyte differentiation in tissue culture and to analyse whether MIA/CD-RAP may serve as a useful marker to control chondrocyte differentiation in in vitro tissue engineering. Our data provide evidence that measuring MIA in tissue culture supernatant by a quantitative ELISA can be used as a marker for differentiated chondrocytes. (C) 2003 Elsevier Science Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACID-SENSITIVE PROTEIN; MALIGNANT-MELANOMA; SERUM MARKER; CARTILAGE; EXPRESSION; COLLAGEN; CLONING; GENE; MIA; CD-RAP; chondrocyte; differentiation; tissue engineering |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Aug 2021 12:38 |
| Last Modified: | 04 Aug 2021 12:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38741 |
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