Schmitt, Rüdiger (2003) Helix rotation model of the flagellar rotary motor. BIOPHYSICAL JOURNAL, 85 (2). pp. 843-852. ISSN 0006-3495
Full text not available from this repository.Abstract
A new model of the flagellar motor is proposed that is based on established dynamics of the KcsA potassium ion channel and on known genetic, biochemical, and biophysical facts, which accounts for the mechanics of torque generation, force transmission, and reversals of motor rotation. It predicts that proton (or in some species sodium ion) flow generates short, reversible helix rotations of the MotA-MotB channel complex (the stator) that are transmitted by Coulomb forces to the FliG segments at the rotor surface. Channels are arranged as symmetric pairs, S and T, that swing back and forth in synchrony. S and T alternate in attaching to the rotor, so that force transmission proceeds in steps. The sense of motor rotation can be readily reversed by conformationally switching the position of charged groups on the rotor so that they interact with the stator during the reverse rather than forward strokes. An elastic device accounts for the observed smoothness of rotation and a prolonged attachment of the torque generators to the rotor, i.e., a high duty ratio of each torque-generating unit.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FORCE-GENERATING UNITS; ROTOR PROTEIN FLIG; ESCHERICHIA-COLI; SALMONELLA-TYPHIMURIUM; BASAL-BODY; RHODOBACTER-SPHAEROIDES; INTERMITTENT ROTATION; BACTERIAL CHEMOTAXIS; VIBRIO-ALGINOLYTICUS; RHIZOBIUM-MELILOTI; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Aug 2021 12:39 |
| Last Modified: | 04 Aug 2021 12:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38742 |
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