Schmid, Daniela and Behrens, Gundula and Matthews, Charles E. and Leitzmann, Michael F. (2016) Physical Activity and Risk of Colon Cancer in Diabetic and Nondiabetic US Adults. MAYO CLINIC PROCEEDINGS, 91 (12). pp. 1693-1705. ISSN 0025-6196, 1942-5546
Full text not available from this repository. (Request a copy)Abstract
Objective: To determine whether moderate to vigorous physical activity is associated with a decreased risk of colon cancer in diabetic patients. Patients and Methods: We evaluated the association between physical activity and colon cancer in 25,753 patients with a self-reported history of diabetes and in 274,965 nondiabetic individuals from the National Institutes of Health-AARP Diet and Health Study who were aged 50 to 71 years in 1995-1996. Moderate to vigorous physical activity was assessed at baseline using a self-administered questionnaire. Follow-up for colon cancer incidence extended to December 31, 2011. Results: During 13.0 years of follow-up, 480 diabetic patients and 4151 nondiabetic individuals had development of colon cancer. Among diabetic patients, compared with never/rarely engaging in physical activity, more than 7 h/wk of physical activity exhibited a reduced risk of colon cancer in the age-and sex-adjusted model (hazard ratio [HR], 0.74; 95% CI, 0.56-0.996; P =.16 for trend). This association was attenuated and no longer statistically significant after additional control for other covariates (HR, 0.78; 95% CI, 0.58-1.05; P =.29 for trend). By comparison, physical activity was inversely related to colon cancer risk in nondiabetic individuals (multivariate-adjusted HR, 0.81; 95% CI, 0.73-0.89; P<. 001 for trend). Conclusion: In this investigation of the relationship between physical activity and colon cancer in diabetic patients, we found a statistically significant inverse relationship in the age-and sex-adjusted model, which was no longer statistically significant in the multivariate-adjusted model. A reduced risk was noted among nondiabetic individuals, irrespective of other covariates. Future studies with a larger number of participants are required to explore whether physical activity beneficially affects colon cancer risk among diabetic patients. (C) 2016 Mayo Foundation for Medical Education and Research
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SERUM 25-HYDROXYVITAMIN D; NIH-AARP DIET; COLORECTAL-CANCER; INSULIN SENSITIVITY; RECTAL-CANCER; LIFE-STYLE; INFLAMMATORY MARKERS; SEDENTARY BEHAVIOR; GLUCOSE-TOLERANCE; NATIONAL-HEALTH; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Apr 2019 11:19 |
| Last Modified: | 10 Apr 2019 11:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3877 |
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