Aigner, Achim and Buesen, Roland and Gant, Tim and Gooderham, Nigel and Greim, Helmut and Hackermuller, Jorg and Hubesch, Bruno and Laffont, Madeleine and Marczylo, Emma and Meister, Gunter and Petrick, Jay S. and Rasoulpour, Reza J. and Sauer, Ursula G. and Schmidt, Kerstin and Seitz, Herve and Slack, Frank and Sukata, Tokuo and van der Vies, Saskia M. and Verhaert, Jan and Witwer, Kenneth W. and Poole, Alan (2016) Advancing the use of noncoding RNA in regulatory toxicology: Report of an ECETOC workshop. REGULATORY TOXICOLOGY AND PHARMACOLOGY, 82. pp. 127-139. ISSN 0273-2300, 1096-0295
Full text not available from this repository. (Request a copy)Abstract
The European Centre for the Ecotoxicology and Toxicology of Chemicals (ECETOC) organised a workshop to discuss the state-of-the-art research on noncoding RNAs (ncRNAs) as biomarkers in regulatory toxicology and as analytical and therapeutic agents. There was agreement that ncRNA expression profiling data requires careful evaluation to determine the utility of specific ncRNAs as biomarkers. To advance the use of ncRNA in regulatory toxicology, the following research priorities were identified: (1) Conduct comprehensive literature reviews to identify possibly suitable ncRNAs and areas of toxicology where ncRNA expression profiling could address prevailing scientific deficiencies. (2) Develop consensus on how to conduct ncRNA expression profiling in a toxicological context. (3) Conduct experimental projects, including, e.g., rat (90-day) oral toxicity studies, to evaluate the toxicological relevance of the expression profiles of selected ncRNAs. Thereby, physiological ncRNA expression profiles should be established, including the biological variability of healthy individuals. To substantiate the relevance of key ncRNAs for cell homeostasis or pathogenesis, molecular events should be dose -dependently linked with substance induced apical effects. Applying a holistic approach, knowledge on ncRNAs, 'omics and epigenetics technologies should be integrated into adverse outcome pathways to improve the understanding of the functional roles of ncRNAs within a regulatory context. Crown Copyright (C) 2016 Published by Elsevier Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEAT-SHOCK RESPONSE; MICRORNA PROFILES; BREAST-CANCER; EXPRESSION PROFILES; DNA METHYLATION; PATERNAL STRESS; GENE-EXPRESSION; EMERGING ROLES; PLANT MIRNAS; IN-VITRO; Noncoding RNA (ncRNA); Regulatory toxicology; Biomarker; Gene expression; Phenotypic consequence; Adverse-outcome-pathway |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I > Prof. Dr. Gunter Meister |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Mar 2019 14:26 |
| Last Modified: | 10 Apr 2019 11:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3878 |
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