Walz, Johanna M. and Bemme, Sebastian and Pielen, Amelie and Aisenbrey, Sabine and Breuss, Helge and Alex, Anne F. and Wagenfeld, Lars and Schiedel, Susanne and Krohne, Tim U. and Stahl, Andreas (2016) The German ROP Registry: data from 90 infants treated for retinopathy of prematurity. ACTA OPHTHALMOLOGICA, 94 (8). E744-E752. ISSN 1755-375X, 1755-3768
Full text not available from this repository. (Request a copy)Abstract
PurposeThe German retinopathy of prematurity (ROP) Registry collects data on treated ROP in a multicentre approach to analyse epidemiology and treatment patterns of severe ROP. MethodsNine centres entered data from 90 treated ROP infants (born between January 2011 and December 2013) into a central database. Analysis included incidence rate of severe ROP, demographic data, stage of ROP, treatment patterns, recurrence rates, relevant comorbidities and ophthalmological or systemic complications associated with treatment. ResultsTreatment rate for ROP was 3.2% of the screened population. The most frequent ROP stage at time of treatment was zone II, stage 3+ (137 eyes). Treatment was bilateral in 97% of infants. Treatment patterns changed over time from 7% anti-vascular endothelial growth factor (VEGF) monotherapy in 2011 to 32% in 2014. Overall, laser treatment was the predominant treatment. However, all infants with zone I disease received anti-VEGF treatment. About 19% of infants required retreatment (16% of laser-treated and 21% of anti-VEGF treated infants). Mean time between first and second treatment was 3.8weeks (11days) for laser-treated and 10.4weeks (+/- 60days) for anti-VEGF-treated infants. ConclusionThis study is the first multicentre analysis of severe ROP in Germany. The identified treatment patterns find laser as the most prevalent form of therapy, with an increasing use of anti-VEGF therapy over recent years. Recurrence rates were relatively high overall with slightly higher recurrence rates and later recurrence times in the anti-VEGF group. Anti-VEGF was predominantly used for high-risk stages like AP-ROP and zone I disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LASER PHOTOCOAGULATION; WEIGHT-GAIN; BEVACIZUMAB; GUIDELINES; anti-VEGF; laser; retinopathy of prematurity; treatment pattern |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Apr 2019 11:37 |
| Last Modified: | 10 Apr 2019 11:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3881 |
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