Kleinjung, Tobias and Woenckhaus, Matthias and Bachthaler, Maike and Wolff, Johannes E. A. and Wolf, Stephan R. (2003) Langerhans' cell histiocytosis with bilateral temporal bone involvement. AMERICAN JOURNAL OF OTOLARYNGOLOGY, 24 (4). pp. 265-270. ISSN 0196-0709
Full text not available from this repository. (Request a copy)Abstract
Background: Langerhans' cell histiocytosis (LCH) is a rare disease with variable clinical appearance. The etiology of LCH remains unclear to date. It is currently believed that clonal accumulation and proliferation of CD-la-positive Langerhans' cells are causative. Methods: A 2-year-old boy presented with hypacusis and disturbance of balance. Auditory brainstem-evoked responses (ABRs) revealed severe bilateral labyrinthine hearing loss. Magnetic resonance imaging (MRI) showed inflammatory changes with bone erosion in both temporal bones including labyrinthine systems and mastoid processes. Results: During bilateral surgical exploration, fragile slightly yellowish tissue with necrotic areas was found that turned out to be LCH on histology. Chemotherapy with vinblastine and prednisone was subsequently initiated, leading to continuing complete remission. Conclusions: The initial presentation of LCH with bilateral temporal bone involvement is a very rare condition. The signs and symptoms of otologic histiocytosis can mimic those of acute and chronic infectious ear disease. Only a surgically obtained biopsy leads to definitive diagnosis and appropriate therapy. (C) 2003 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EOSINOPHILIC GRANULOMA; PEDIATRIC-PATIENT; MANAGEMENT; NECK; HEAD; CT; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Sep 2021 09:11 |
| Last Modified: | 06 Sep 2021 09:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38831 |
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