Rothoerl, Ralf Dirk and Schebesch, Karl Michael and Faltermeier, Rupert and Woertgen, Chris and Brawanski, Alexander (2003) Lack of correlation between Xenon(133) and near infrared spectroscopy/indocyanine green rCBF measurements. NEUROLOGICAL RESEARCH, 25 (5). pp. 528-532. ISSN 0161-6412
Full text not available from this repository.Abstract
In recent literature there are some reports describing cerebral blood flow measurements by a near infrared spectroscopy-based technique with indocyanine-green as an absorbant. To our knowledge there is no systematical study which evaluates this technique in comparison to absolute cerebral blood flow measurements. Ten patients suffering from head injury (n = 9) or subarachnoid hemorrhage (n = 1) were included. Twenty measurements of cerebral blood flow were performed, employing a Xenon(133) clearance technique. Near-infrared spectroscopy measurements were performed with the Somanetics 4100 System. Indocyanine-green was given at a total dose of 0.2 mg kg(-1) bodyweight intravenously. The indocyanine-green curve was compared to cerebral blood flow measurements according to rising time and area under the curve as suggested in the literature. No correlation between the indocyanine-green clearance curve and the Xenon(133) cerebral blood flow measurements could be found. Neither the area under the curve (p = 0.93) nor the rising time (p = 0.75) showed a statistically significant correlation. The near-infrared spectroscopy based indocyanine-green clearance curve measurement method of cerebral blood flow seems not to give reliable results using simple mathematical models (area under the curve and rising time). In view of our findings, we have serious reservations in the potential of this technique.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CEREBRAL BLOOD-FLOW; INDOCYANINE GREEN; DYE-DILUTION; HEMODYNAMICS; CIRCULATION; DISEASE; TIME; indocyanine green; near infrared spectroscopy; cerebral blood flow |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurochirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Sep 2021 09:44 |
| Last Modified: | 08 Sep 2021 09:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38873 |
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