Zietz, B. and Herfarth, H. and Paul, G. and Ehling, A. and Mueller-Ladner, Ulf and Schoelmerich, Juergen and Schaeffler, Andreas (2003) Adiponectin represents an independent cardiovascular risk factor predicting serum HDL-cholesterol levels in type 2 diabetes. FEBS LETTERS, 545 (2-3). pp. 103-104. ISSN 0014-5793
Full text not available from this repository.Abstract
Low levels of high-density lipoprotein (HDL)-cholesterol represent an independent cardiovascular risk factor and, besides reduced physical activity, mechanisms leading to decreased HDL-cholesterol levels are not known. We aimed to test the hypothesis, that adiponectin provides a missing link between type 2 diabetes and low levels of HDL-cholesterol, independent from common metabolic risk factors. 523 patients with type 2 diabetes were investigated for adiponectin serum levels and parameters of lipid metabolism. Even after correction for age, gender, BMI and fasting insulin concentration, serum levels of adiponectin were highly significant (P < 0.0001) and positively (regression analysis: r = 0.86) associated with HDL-cholesterol levels in type 2 diabetes. Conclusion: adiponectin seems to predict HDL-cholesterol levels in patients with diabetes mellitus type 2. Low levels of adiponectin are associated with low levels of HDL-cholesterol independently from common metabolic risk factors and therefore represent an independent cardiovascular risk factor in type 2 diabetes. Thus, adiponectin is a potentially new drug target in the treatment of dyslipidaemia. (C) 2003 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ADIPOSE; PROTEIN; OBESITY; diabetes; adiponectin; adipocyte; high-density lipoprotein-cholesterol; lipid metabolism |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 Aug 2021 04:50 |
| Last Modified: | 11 Aug 2021 04:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38894 |
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