Lehmann, HW and von Landenberg, P and Modrow, S (2003) Parvovirus B19 infection and autoimmune disease. AUTOIMMUNITY REVIEWS, 2 (4). pp. 218-223. ISSN 1568-9972,
Full text not available from this repository. (Request a copy)Abstract
Human parvovirus B19 infections may cause a widespread benign and self-limiting disease in children and adults, known as erythema infectiosum or fifth disease. A variety of further manifestations are associated with the infection such as arthralgias, arthritis, leukopenia and thrombocytopenia, anemia and vasculitis, spontaneous abortion and hydrops fetalis in pregnant women. Both in children and adults parvovirus B19 infections have been frequently implicated. as a cause or trigger of various forms of autoimmune diseases affecting joints, connective tissue and large and small vessels. In addition,. autoimmune neutropenia, thrombocytopenia and hemolytic anemia are known as sequelae of B19 infection. The molecular basis of the autoimmune phenomena and resultant pathogenesis is unclear. The involvement of molecular mimicry between cellular and viral proteins, the induction of enhanced cytokine production via the viral transactivator protein NS1 and the phospholipase A2-like activity of the capsid protein VP1 may contribute to the induction of autoimmune reactions. All the known data and the potential mechanisms involved in the pathogenesis will be discussed in this review. (C) 2003 Elsevier Science B.V All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IDIOPATHIC THROMBOCYTOPENIC PURPURA; SYSTEMIC-LUPUS-ERYTHEMATOSUS; NECROSIS-FACTOR-ALPHA; BONE-MARROW; NS1 PROTEIN; DNA; CHILDHOOD; PERSISTENCE; ASSOCIATION; VIRUS; parvovirus B19 infection; arthralgia-arthritis; juvenile rheumatoid arthritis; anti-phospholipid syndrome; autoimmune reaction |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 May 2021 06:47 |
| Last Modified: | 19 May 2021 06:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38914 |
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