Bacterial translocation in the gut

Wiest, Reiner and Rath, Heiko C. (2003) Bacterial translocation in the gut. BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 17 (3). pp. 397-425. ISSN 1521-6918, 1532-1916

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Abstract

The human gastrointestinal tract is colonized by a dense population of microorganisms, referred to as the bacterial flora. Although the gut provides a functional barrier between these organisms and the host, bacterial translocation is a common event in the healthy person. However, in critically ill patients, with various underlying diseases, this bacterial translocation may lead to infections and consequently to a further reduction in general health status. The mechanism of bacterial translocation is widely, and somehow controversially investigated in vitro and in animal models. In human studies, several diseases have been associated with bacterial translocation. However, methodological shortcomings, insufficient populations and conflicting results leave many open questions. This is also reflected in the various published therapeutic strategies. To overcome this problem more investigations in humans are needed, especially in techniques for detecting bacterial translocation.

Item Type: Article
Additional Information: doi ausgetauscht /gup
Uncontrolled Keywords: SMALL-BOWEL TRANSPLANTATION; NITRIC-OXIDE SYNTHASE; MESENTERIC LYMPH-NODES; MULTIPLE-ORGAN FAILURE; BACTERICIDAL/PERMEABILITY-INCREASING PROTEIN; EXPERIMENTAL OBSTRUCTIVE-JAUNDICE; ORNITHINE-ALPHA-KETOGLUTARATE; GRAM-NEGATIVE BACTEREMIA; GASTRO-INTESTINAL TRACT; VERSUS-HOST-DISEASE; intestinal bacteria; bacterial translocation; bacterial overgrowth; intestinal permeability; barrier dysfunction; nitric oxide; mucosal hypoxia; mucosal acidosis; thermal injury; trauma; liver cirrhosis
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Innere Medizin I
Depositing User: Petra Gürster
Date Deposited: 07 Jul 2021 08:57
Last Modified: 07 Jul 2021 08:57
URI: https://pred.uni-regensburg.de/id/eprint/38915

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