Rath, Heiko C. (2003) The role of endogenous bacterial flora: bystander or the necessary prerequisite? EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 15 (6). pp. 615-620. ISSN 0954-691X, 1473-5687
Full text not available from this repository. (Request a copy)Abstract
Abundant experimental and clinical data incriminate microbial factors in the pathogenesis of inflammatory bowel diseases. Commensal bacteria, and their products, provide the constant antigenic stimulus to disequilibrate the mucosal immune system towards an overly aggressive response in a genetically susceptible host with reduced tolerance towards the autologous flora. Not all bacteria have equal proinflammatory capabilities. Some may be even beneficial as demonstrated by the anti-inflammatory effects of so-called probiotics. Further investigations are needed to translate the clear experimental and clinical evidence into benefit for the patients. (C) 2003 Lippincott Williams Wilkins.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INFLAMMATORY-BOWEL-DISEASE; RESIDENT INTESTINAL FLORA; HLA-B27 TRANSGENIC RATS; NORMAL LUMINAL BACTERIA; CROHNS-DISEASE; ULCERATIVE-COLITIS; DEFICIENT MICE; ESCHERICHIA-COLI; BACTEROIDES-VULGATUS; CHEMOTACTIC PEPTIDE; endogenous bacteria; inflammatory bowel disease; microbial factors; tolerance; antibiotics; probiotics |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 07 Jul 2021 08:54 |
| Last Modified: | 07 Jul 2021 08:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38925 |
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