Babilas, R and Landthaler, M and Szeimies, RM (2003) Actinic keratoses. HAUTARZT, 54 (6). pp. 551-560. ISSN 0017-8470,
Full text not available from this repository. (Request a copy)Abstract
Actinic keratoses are defined as proliferation of cytologically atypical keratinocytes in the zone of epidermal-dermal junction in photodamaged skin. In the northern hemisphere the prevalence of actinic keratoses ranges depending on different epidemiological studies from 11% to 25% for people aged 40 or older. The main cause of actinic keratoses is exposure to UVB radiation in sunlight. UVB radiation induces mutations in the telomerase gene and in the tumor suppressor gene p53, which can also be detected in invasive squamous cell carcinoma. The only histological parameter to distinguish between actinic keratoses and SCC is the level of invasiveness. The risk for actinic keratoses to develop into SCC is about 16% over 10 years. For this reason and because of the high prevalence of actinic keratoses, it has been suggested to replace the term "actinic keratosis" with "intraepidermal squamous cell carcinoma" to better characterize the lesion. In the following review recent aspects of pathogenesis and therapy of actinic keratoses are discussed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SQUAMOUS-CELL CARCINOMA; SKIN-CANCER; SOLAR KERATOSES; CREAM; 5-FLUOROURACIL; CHEMOTHERAPY; PERSPECTIVE; intraepidermal squamous cell carcinoma; invasive squamous cell carcinoma; p53-mutation; telomerase-mutation; photo damage; sun protection |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 May 2021 06:26 |
| Last Modified: | 19 May 2021 06:26 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38931 |
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