Holmer, SR and Bickeboller, H and Hengstenberg, C and Rohlmann, F and Engel, S and Lowel, H and Mayer, B and Erdmann, J and Baier, C and Klein, G and Riegger, GAJ and Schunkert, H (2003) Angiotensin converting enzyme gene polymorphism and myocardial infarction a large association and linkage study. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 35 (6): PII S1357-. pp. 955-962. ISSN 1357-2725,
Full text not available from this repository.Abstract
The DD genotype of the angiotensin converting enzyme (ACE) polymorphism has been associated with myocardial infarction (MI). However, sample sizes of many case-control studies showing positive association were small and data were inconsistent. Furthermore, no family-based study is available. In a case-control study frequencies of the ACE genotypes were compared in 1319 unrelated patients with previous MI before 60 years of age (616 from the MONICA Augsburg region and 703 from rehabilitation centers in south Germany) and in 2381 population controls from the MONICA Augsburg study region). Furthermore, linkage and association of the ACE I/D polymorphism with MI were tested in 246 informative families using the sib-transmission/disequilibrium test (S-TDT). Overall, no excess of the D allele was found in MI patients (frequency 0.53 versus 0.57 in the general population; P = 0.2). The ACEDD genotype was even slightly less frequent in groups with MI compared to the general population controls (0.26 versus 0.33 in women and 0.28 versus 0.33 in men). Similar results were also obtained in 247 men with low cardiovascular risk. In the family-based study, the frequency of the D allele was not different in siblings with or without previous MI (0.53 versus 0.50, respectively; S-TDT P = 0.15) indicating no linkage or association of the D allele with MI. In a case-control study of MI patients and controls from the general population as well as a family study neither association nor linkage of the ACED allele with MI was detected despite sample sizes that were among the largest samples studied so far. (C) 2003 Elsevier Science Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ISCHEMIC-HEART-DISEASE; DELETION POLYMORPHISM; INSERTION/DELETION POLYMORPHISM; RISK; ALLELE; NIDDM; angiotensin converting enzyme; polymorphism; myocardial infarction; linkage; family study |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 May 2021 11:02 |
| Last Modified: | 18 May 2021 11:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38935 |
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