Langguth, B and Eichhamfmer, P and Wiegnd, R and Marienhegen, J and Maenner, P and Jacob, P and Hajak, G (2003) Neuronavigated rTMS in a patient with chronic tinnitus. Effects of 4 weeks treatment. NEUROREPORT, 14 (7). pp. 977-980. ISSN 0959-4965, 1473-558X
Full text not available from this repository. (Request a copy)Abstract
Clinical, neurophysiological and neuroimaging data suggest that chronic tinnitus resembles neuropsychiatric syndromes characterised by focal brain activation. Low frequency repetitive transcranial magnetic stimulation (rTMS) has been proposed as an efficient method in treating brain hyperexcitability disorders. In one patient suffering from chronic tinnitus, [F-18]deoxyglucose PET revealed increased metabolic activity in a circumscript area of the left primary auditory cortex (PAC). The effect of MRI and PET guided neuronavigated 1 Hz rTMS of this area was evaluated in a single-blind, sham-controlled, cross-over manner, followed by a 4-week open treatment. Following active stimulation there was a remarkable effect, enduring several weeks, on tinnitus sensation, which was paralleled by altered cortical excitability. These findings suggest that neuronavigated rTMS of increased PAC activity might offer a new option for treating auditory phantom perceptions like chronic tinnitus.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSCRANIAL MAGNETIC STIMULATION; HUMAN MOTOR CORTEX; AUDITORY-CORTEX; EXCITABILITY; DEPOTENTIATION; PLASTICITY; MODULATION; DEPRESSION; BRAIN; chronic tinnitus; cortical excitability; neuronavigated transcranial magnetic stimulation; paired pulse transcranial magnetic stimulation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde Medicine > Lehrstuhl für Psychiatrie und Psychotherapie Medicine > Abteilung für Nuklearmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 May 2021 06:28 |
| Last Modified: | 18 May 2021 06:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38990 |
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