Armeanu, S and Lauer, UM and Smirnow, I and Schenk, M and Weiss, TS and Gregor, M and Bitzer, M (2003) Adenoviral gene transfer of tumor necrosis factor-related apoptosis-inducing ligand overcomes an impaired response of hepatoma cells but causes severe apoptosis in primary human hepatocytes. CANCER RESEARCH, 63 (10). pp. 2369-2372. ISSN 0008-5472,
Full text not available from this repository.Abstract
Ligands of the tumor necrosis factor family play key roles in liver pathogenesis. The ligand tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is unique, because it is thought to be nontoxic to normal cells while killing a broad range of tumor cells. However, hepatocellular carcinoma is considered resistant to soluble TRAIL treatment. Therefore, a direct gene transfer of TRAIL to malignant cells is part of an alternative delivery strategy. We show that an adenoviral gene transfer (Ad-TRAIL) overcomes an impaired response of hepatocellular carcinoma cell lines to soluble TRAIL, but the transduction of primary human hepatocytes revealed a high number of apoptotic cells. Our data imply that Ad-TRAIL administration in vivo must either be restricted to tumor tissue or controlled by a tumor-specific promoter to avoid severe liver damage in human trials.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANTITUMOR-ACTIVITY; HEPATOCELLULAR-CARCINOMA; CANCER-CELLS; IN-VIVO; TRAIL; THERAPY; LIVER; EXPRESSION; INFECTION; DEATH; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 May 2021 11:11 |
| Last Modified: | 18 May 2021 11:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38998 |
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