Cholestasis and vomiting: Unusual differential diagnosis in a case of Peutz-Jeghers syndrome

Mandraka, Falitsa and Zuelke, C. and Lock, G. (2003) Cholestasis and vomiting: Unusual differential diagnosis in a case of Peutz-Jeghers syndrome. DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 128 (18). pp. 984-988. ISSN 0012-0472

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Abstract

History and clinical findings: A 54-year-old patient with painless jaundice and vomiting had been diagnosed with a Peutz-Jeghers syndrome 20 years before. Investigations: The blood analysis showed a cholestatic constellation as well as increased transaminases. Sonographic, radiological, endoscopic and histological findings indicated multiple hamartomatous polyps of the Peutz-jeghers' type in the entire small and large bowel with occlusion of the papilla of Vater and the superior gastrointestinal tract by a big polyp. Treatment and course: After an initial percutaneous transhepatic cholangiographic drainage, Whipple's operation and a segmental resection of small and large bowel were performed. A highly differentiated adenocarcinoma of the duodenum was found in the resected specimen. Conclusion: This case demonstrates the potentially severe complications of a Peutz-Jeghers syndrome that had been neglected for years.

Item Type: Article
Uncontrolled Keywords: SEX CORD TUMOR; ANNULAR TUBULES; POLYPS; CARCINOMA; CANCER;
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Chirurgie
Medicine > Lehrstuhl für Innere Medizin I
Depositing User: Dr. Gernot Deinzer
Date Deposited: 13 Sep 2021 08:06
Last Modified: 13 Sep 2021 08:06
URI: https://pred.uni-regensburg.de/id/eprint/39013

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