Evers, Stefan and Förderreuther, Stefanie and Henkel, Karsten and Kraft, Andrea and Marziniak, Martin and May, Arne and Kunesch, Erwin and Lüttmann, Rainer Jens (2003) Misoprostol in the treatment of trigeminal neuralgia associated with multiple sclerosis. JOURNAL OF NEUROLOGY, 250 (5). pp. 542-545. ISSN 0340-5354
Full text not available from this repository. (Request a copy)Abstract
Multiple sclerosis can be associated with trigeminal neuralgia which is often difficult to treat in this specific condition. We performed an open prospective trial on the efficacy and safety of the prostaglandin-E-1-analogue misoprostol (600 mug per day) in the reduction of attack frequency and pain intensity in patients with refractory trigeminal neuralgia associated with multiple sclerosis. Eighteen patients completed the study period and 14 of them showed a reduction of more than 50% in attack frequency and intensity beginning five days after treatment onset. There were only mild and transient drug related side effects in three patients. One patient stopped taking misoprostol after the study period because of severe menorrhagia. Our results suggest that misoprostol is effective and safe in the treatment of this specific type of refractory trigeminal neuralgia.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LAMOTRIGINE; MECHANISMS; ANALOG; trigeminal neuralgia; misoprostol; multiple sclerosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Sep 2021 10:15 |
| Last Modified: | 13 Sep 2021 10:15 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39061 |
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