Johann, Monika and Wiegand, R. and Kharraz, A. and Bobbe, G. and Sommer, G. and Hajak, Goeran and Wodarz, Norbert and Eichhammer, Peter (2003) Repetitiv transcranial magnetic stimulation in nicotine dependence. PSYCHIATRISCHE PRAXIS, 30. S129-S131. ISSN 0303-4259
Full text not available from this repository.Abstract
70-80% of regular smokers fulfill the ICD-10-criteria of dependence. In Germany, approximately 120 000 deaths per year are caused by tobacco-associated diseases. In contrast, therapeutic interventions, such as nicotine substitution or bupropione, yield poor abstinence rates of 30% after 12 months, at best. In animal experiments, repetitive transcranial magnetic stimulation (rTMS) exhibited modulatory effects on dopaminergic neurotransmission in regions of the so-called reward system. This pilot study should evaluate, if rTMS could modulate subjective craving for tobacco, which quite often leads to relapse to smoking. Therefore, 11 tobacco-dependent cigarette smokers were randomly assigned to a course of verum- and placebo-rTMS on consecutive days. Craving, as measured by a visual analogue scale, is significantly decreased after Verumstimulation compared to placebo-stimulation intra-individually. This encourages further studies to clarify, if rTMS might be helpful in achieving higher tobacco abstinence rates in smokers willing to quits.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SMOKING; DOPAMINE; STATES; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Sep 2021 13:17 |
| Last Modified: | 13 Sep 2021 13:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39085 |
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