Rohrmeier, Thomas and Putzhammer, Albert and Sartor, Heino and Knapp, Michael and Albus, Margot and Borrmann-Hassenbach, Margitta and Lichtermann, Dirk and Wildenauer, Dieter and Schwab, Sibylle and Maier, Wolfgang and Klein, Helmfried E. and Eichhammer, Peter (2003) No association of the - 141C Ins/Del polymorphism of the dopamine D-2 receptor with schizophrenia. PSYCHIATRISCHE PRAXIS, 30. S212-S215. ISSN 0303-4259
Full text not available from this repository. (Request a copy)Abstract
Recently, a putative functional polymorphism (-141C Ins/Del) in the 5'-flanking region of the dopamine D-2 receptor was found. An association of the Ins allele with schizophrenia has been described in a Japanese sample. In the present study this association was examined in a German schizophrenia patient population. In a family based approach 190 German family trios were analyzed for the -141C Ins/Del genotype. Using the transmission disequilibrium test (TDT) we found no evidence for an association of the Ins allele with schizophrenia (TDT = 0.152, P = 0.696). In parallel, we performed an independent case control study with 268 schizophrenic patients and 244 controls. Again, we did not detect an overrepresentation of the Ins allele in patients (P = 0.124). Thus, our data do not support the hypothesis that the -141C Ins variant plays a major role in predisposition to schizophrenia. To confirm our conclusion further preferentially family based studies are needed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROMOTER POLYMORPHISM; FUNCTIONAL POLYMORPHISM; LINKAGE DISEQUILIBRIUM; JAPANESE SUBJECTS; -141C INS/DEL; GENE; REGION; TRANSMISSION; VARIANT; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Sep 2021 12:20 |
| Last Modified: | 14 Sep 2021 12:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39093 |
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