Schuessler, P. and Kluge, M. and Gamringer, W. and Wetter, T. C. and Yassouridis, A. and Uhr, M. and Rupprecht, R. and Steiger, A. (2016) Corticotropin-releasing hormone induces depression-like changes of sleep electroencephalogram in healthy women. PSYCHONEUROENDOCRINOLOGY, 74. pp. 302-307. ISSN 0306-4530,
Full text not available from this repository. (Request a copy)Abstract
We reported previously that repetitive intravenous injections of corticotropin-releasing hormone (CRH) around sleep onset prompt depression-like changes in certain sleep and endocrine activity parameters (e.g. decrease of slow-wave sleep during the second half of the night, blunted growth hormone peak, elevated cortisol concentration during the first half of the night). Furthermore a sexual dimorphism of the sleep-endocrine effects of the hormones growth hormone-releasing hormone and ghrelin was observed. In the present placebo-controlled study we investigated the effect of pulsatile administration of 4 x 50 mu g CRH on sleep electroencephalogram (EEG) and nocturnal cortisol and GH concentration in young healthy women. After CRH compared to placebo, intermittent wakefulness increased during the total night and the sleep efficiency index decreased. During the first third of the night, REM sleep and stage 2 sleep increased and sleep stage 3 decreased. Cortisol concentration was elevated throughout the night and during the first and second third of the night. GH secretion remained unchanged. Our data suggest that after CRH some sleep and endocrine activity parameters show also depression-like changes in healthy women. These changes are more distinct in women than in men. (C) 2016 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SLOW-WAVE SLEEP; NON-REM SLEEP; EEG TOPOGRAPHY; BRAIN TOPOGRAPHY; GHRH; GHRELIN; RAT; MEN; SECRETION; PITUITARY; CRH; Sleep; Sleep EEG; Cortisol; GH |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Apr 2019 07:23 |
| Last Modified: | 12 Apr 2019 07:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3919 |
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