Castrop, Hayo and Klar, Juergen and Wagner, Charlotte and Hoecherl, Klaus and Kurtz, Armin (2003) General inhibition of renocortical cyclooxygenase-2 expression by the renin-angiotensin system. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 284 (3). F518-F524. ISSN 1931-857X
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Because across-the-board data indicate that renin and cyclooxygenase-2 (COX-2) expression in the kidney cortex are regulated in parallel and because ANG II can inhibit COX-2 expression, the purpose of our study was to characterize a potential general inhibitory feedback of the renin-angiotensin system on renocortical COX-2 expression in vivo. Rats were fed a high-, normal-, or low-salt diet or were chronically infused with furosemide (60 mg.kg(-1).day(-1)) or the left renal artery was clipped, and the animals were treated in addition to or without the angiotensin-converting enzyme inhibitor ramipril (10 mg.kg(-1).day(-1)). A high- salt diet reduced expression of COX-2, whereas a low-salt diet, furosemide infusion, and renal artery stenosis stimulated COX-2 expression. Additional angiotensin-converting enzyme inhibition led to further increases in renocortical COX-2 expression by 62, 136, 300, 50, and 70% for a high-, normal-, and low-salt diet, furosemide infusion, and renal artery stenosis, respectively. Thus our data suggest a general inhibitory effect of the renin-angiotensin system on renocortical COX-2 expression.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MACULA DENSA; STIMULATED RENIN; RENOVASCULAR HYPERTENSION; RAT-KIDNEY; SECRETION; CHLORIDE; BLOCKADE; RELEASE; COX-2; renin; angiotensin-converting enzyme inhibition; renal cortex; prostaglandins |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 615 Pharmacy |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Sep 2021 10:21 |
| Last Modified: | 15 Sep 2021 10:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39213 |
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