Zoidl, G. and Grifka, J. and Boluki, D. and Willburger, R. E. and Zoidl, C. and Kramer, J. and Dermietzel, R. and Faustmann, Pedro M. (2003) Molecular evidence for local denervation of paraspinal muscles in failed-back surgery/postdiscotomy syndrome. CLINICAL NEUROPATHOLOGY, 22 (2). pp. 71-77. ISSN 0722-5091
Full text not available from this repository. (Request a copy)Abstract
A study was performed to analyze whether local denervation of the medial branch of the dorsal ramus of the lumbar spinal nerve occurs in a patient with postoperative failed-back surgery syndrome/postdiscotomy syndrome (FBSS/PDS). We investigated the effect of the loss of innervation of the multifidus muscle on neuronal nitrite oxide synthetase (n-NOS) and endothelial nitrite oxide synthetase (e-NOS) applying real-time RT-PCR and immunohistochemistry. Our study demonstrates a substantial reduction of n-NOS expression, supporting the view that local denervation of the multifidus is involved in the pathology of FBSS. No regulation of e-NOS was detectable. Interestingly, this change is region-specific and does not occur throughout the entire multifidus segment. This result supports the hypothesis that local denervation of the multifidus muscle is involved in the pathology of FBSS/ PDS.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NITRIC-OXIDE SYNTHASE; LUMBAR DISC HERNIATION; MULTIFIDUS MUSCLE; SURGERY SYNDROME; EPIDURAL FIBROSIS; PAIN; EXPRESSION; MORPHOLOGY; GENE; NOS; failed-back syndrome, postdiscotomy syndrome; immunohistochemistry; realtime RT-PCR; NOS; multifidus muscle; denervation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Orthopädie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Sep 2021 10:37 |
| Last Modified: | 15 Sep 2021 10:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39224 |
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