Penzkofer, Alfons and Kateriya, Suneel and Hegemann, Peter (2016) Photodynamics of the optogenetic BLUF coupled photoactivated adenylyl cyclases (PACs). DYES AND PIGMENTS, 135. pp. 102-112. ISSN 0143-7208, 1873-3743
Full text not available from this repository. (Request a copy)Abstract
Optogenetics is a fast developing science that combines gene biology and optics to new research fields in neuroscience and cell biology. In the introduction a short literature update of optogenetic tools is given with some emphasis on rhodopsin and flavin based optogenetic tools. Then the BLUF coupled photo activated adenylyl cyclases (PACs) are discussed (BLUF = Blue Light sensor Using FAD). The primary photo-dynamics of the BLUF domains is described. A BLUF domain photocycle scheme and a BLUF domain reaction coordinate scheme are presented. The adenylyl cyclase action of catalytic ATP to cAMP (a cellular second messenger) conversion is described. Light-induced cyclase activity of BLUF coupled photoactivated adenylyl cyclases (BLUF-PACs) is analyzed. Optogenetic BLUF-PAC applications are shortly reviewed. (C) 2016 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NEG-M STRAIN; EMISSION SPECTROSCOPIC CHARACTERIZATION; FLAGELLATE EUGLENA-GRACILIS; SYNECHOCYSTIS SP PCC6803; PHOTO-DYNAMICS; LIGHT RECEPTOR; CELLULAR CAMP; ENGINEERED PHOTORECEPTORS; RHODOBACTER-SPHAEROIDES; FLUORESCENT PROTEINS; Optogenetic tools; Photoreceptors; Blue light sensors using FAD (BLUFs); Photoactivated adenylyl cyclases (PACs) |
| Subjects: | 500 Science > 530 Physics |
| Divisions: | Physics > Institute of Experimental and Applied Physics > Alumni or Retired Professors > Group Alfons Penzkofer Physics > Institute of Experimental and Applied Physics > Alumni or Retired Professors |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Dec 2019 13:00 |
| Last Modified: | 13 Dec 2019 13:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3924 |
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