Wimmershoff, Monika B. and Hohenleutner, U. and Landthaler, M. (2003) Discoid lupus erythematosus and lupus profundus in childhood: A report of two cases. PEDIATRIC DERMATOLOGY, 20 (2). pp. 140-145. ISSN 0736-8046
Full text not available from this repository. (Request a copy)Abstract
Discoid lupus erythematosus (DLE) is a rare disorder in childhood, with 22 cases reported in the English-language literature. Less than 2% of patients with DLE have an onset before 10 years of age. We describe two children with DLE and lupus profundus with an onset of the disease at the ages of 11 and 15 years and focus on likely histopathologic differences between DLE in children and in adults. Histopathologic characteristics for childhood DLE might be an intense periadnexal and perivascular infiltrate extending into the interstitium and subcutaneous tissue consisting of lymphocytes, histiocytes, eosinophilic granulocytes, and plasma cells and lacking epidermal atrophy. The diagnosis of DLE in our two patients was established by clinicopathologic correlation based on clinical presentation, histologic and immunofluorescent findings in skin biopsy specimens, and the absence of clinical and laboratory evidence of systemic involvement. Therapy with antimalarials resulted in reduction of the skin lesions, but in one patient severe lipoatrophy occurred.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHILDREN; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Sep 2021 06:06 |
| Last Modified: | 20 Sep 2021 06:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39252 |
Actions (login required)
 |
View Item |
