Tombach, Bernd and Benner, Thomas and Reimer, Peter and Schuierer, Gerhard and Fallenberg, Eva-Maria and Geens, Viviane and Wels, Thomas and Sorensen, A. Gregory (2003) Do highly concentrated gadolinium chelates improve MR brain perfusion imaging? Intraindividually controlled randomized crossover concentration comparison study of 0.5 versus 1.0 mol/L gadobutrol. RADIOLOGY, 226 (3). pp. 880-888. ISSN 0033-8419
Full text not available from this repository. (Request a copy)Abstract
PURPOSE: To assess the potential advantages of using a 1.0 mol/L versus 0.5 mol/L 1 gadobutrol formulation for magnetic resonance (MR) brain perfusion imaging. MATERIALS AND METHODS: Forty-three healthy volunteers were enrolled in an intraindividually controlled, randomized crossover comparison study. Two gadobutrol formulations-0.5 and 1.0 mol/L- were randomly injected during two separate treatment periods. For intraindividual comparison of effectiveness parameters, single-section gradient-echo brain perfusion MR imaging was performed under identical conditions for both investigations. Quantitative and qualitative evaluations were performed. Differences between the two gadobutrol formulations were evaluated at analysis of covariance and tested for statistical significance (P < .05) with,, a t test. RESULTS: Use of 1.0 mol/L gadobutrol resulted in a significantly smaller bolus width at half maximum signal intensity decrease, a smaller mean peak time, a higher contrast and contrast-to-noise ratio between gray and white matter, and significant increases in both maximum change in transverse relaxation rate (DeltaR2(max)) and,, I differences in peak enhancement in gray matter among all volunteers (P < .001). In white matter, increases in AR2(max). (P = .262) and in differences in peak enhancement (P = .262) were smaller and not significant (P = .292). Parameter map analysis revealed improved quality and superior contrast in relative regional cerebral blood flow (P = .034) and mean transit time (P < .001). The lack of difference regarding relative regional cerebral blood volume maps was consistent with the use of the same dose of each gadobutrol formulation. CONCLUSION: Brain perfusion images obtained with 1.0 mol/L gadobutrol were superior to those obtained with 0.5 mol/L gadobutrol in healthy volunteers examined with the described MR imaging protoeol. (C) RSNA, 2003.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CEREBRAL BLOOD-FLOW; HIGH-RESOLUTION MEASUREMENT; TRACER BOLUS PASSAGES; CONTRAST AGENTS; MAGNETIC-SUSCEPTIBILITY; VOLUME MAPS; INJECTION; brain, MR; contrast media, comparative studies gadolinium magnetic resonance (MR), contrast media |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Sep 2021 12:51 |
| Last Modified: | 15 Sep 2021 12:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39260 |
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