Lichterfeld, M. and Woehrmann, A. and Schmeisser, N. and Faetkenheuer, G. and Salzberger, B. and Wyen, C. and Schmitz, K. and Sauerbruch, T. and Rockstroh, J. K. (2003) Superior virological efficacy of ritonavir-boosted protease inhibitor regimens compared to single protease inhibitor therapy. EUROPEAN JOURNAL OF MEDICAL RESEARCH, 8 (2). pp. 56-60. ISSN 0949-2321
Full text not available from this repository.Abstract
Low dose-ritonavir boosted protease inhibitors are increasingly being used for the first-line antiretroviral treatment, though their virological efficacy has just poorly been compared to alternative antiretroviral therapies. Here, we retrospectively investigated the virological responses of 316 protease inhibitor-naive HIV patients receiving highly active antiretroviral treatment based on a single (n = 256) or a ritonavir-boosted protease inhibitor (n = 60), both in the background of two nucleoside analogues. By intent-to-treat analysis, a complete initial virological response was achieved in 71.8% of all patients in the single protease inhibitor group (indinavir: 76%, ritonavir: 67.5%, nelfinavir: 70.6%) and in 88.3% (p = 0.008) of patients, treated with a boosted protease inhibitor saquinavir/r: 71.4%, indinavir/r: 92.1%, lopinavir/r: 86.6%). The multivariate risk analysis identified boosted PI treatment as an independent predictor of a complete virological response (OR = 2.8, p=0.02). Viral rebound after an initial complete virological response was observed in 28% and 17% (p = 0.06) Of patients receiving a single or a dual protease inhibitor, respectivery. The rate of durable viral suppression over 12 months was 44.5% and 56.7% (p = 0.09) in the respective study cohorts. Ritonavir-boosted protease inhibitors therefore seem to induce a superior virological response rate and a higher degree of sustained virological suppression.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SAQUINAVIR; ADULTS; HIV-1; antiretroviral therapy; protease inhibitor; pharmacoenhancement |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Sep 2021 06:41 |
| Last Modified: | 20 Sep 2021 06:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39272 |
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