Trudzinski, F. C. and Schlotthauer, U. and Kamp, A. and Hennemann, K. and Muellenbach, R. M. and Reischl, U. and Gaertner, B. and Wilkens, H. and Bals, R. and Herrmann, M. and Lepper, P. M. and Becker, S. L. (2016) Clinical implications of Mycobacterium chimaera detection in thermoregulatory devices used for extracorporeal membrane oxygenation (ECMO), Germany, 2015 to 2016. EUROSURVEILLANCE, 21 (46). pp. 19-26. ISSN 1560-7917,
Full text not available from this repository. (Request a copy)Abstract
Mycobacterium chimaera, a non-tuberculous mycobacterium, was recently identified as causative agent of deep-seated infections in patients who had previously undergone open-chest cardiac surgery. Outbreak investigations suggested an aerosol-borne pathogen transmission originating from water contained in heater-cooler units (HCUs) used during cardiac surgery. Similar thermoregulatory devices are used for extracorporeal membrane oxygenation ( ECMO) and M. chimaera might also be detectable in ECMO treatment settings. We performed a prospective microbiological study investigating the occurrence of M. chimaera in water from ECMO systems and in environmental samples, and a retrospective clinical review of possible ECMO-related mycobacterial infections among patients in a pneumological intensive care unit. We detected M. chimaera in 9 of 18 water samples from 10 different thermoregulatory ECMO devices; no mycobacteria were found in the nine room air samples and other environmental samples. Among 118 ECMO patients, 76 had bronchial specimens analysed for mycobacteria and M. chimaera was found in three individuals without signs of mycobacterial infection at the time of sampling. We conclude that M. chimaera can be detected in water samples from ECMO-associated thermoregulatory devices and might potentially pose patients at risk of infection. Further research is warranted to elucidate the clinical significance of M. chimaera in ECMO treatment settings.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEATER-COOLER UNITS; CARDIOGENIC-SHOCK; AVIUM COMPLEX; PULMONARY-DISEASE; CARDIAC-SURGERY; ADULT PATIENTS; HEART-SURGERY; INFECTION; CONTAMINATION; WATER; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Apr 2019 10:19 |
| Last Modified: | 12 Apr 2019 10:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3940 |
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