Ogonek, Justyna and Juric, Mateja Kralj and Ghimire, Sakhila and Varanasi, Pavankumar Reddy and Holler, Ernst and Greinix, Hildegard and Weissinger, Eva (2016) Immune Reconstitutional after Allogeneic Hematopoietic Stem Cell Transplantation. FRONTIERS IN IMMUNOLOGY, 7: 507. ISSN 1664-3224
Full text not available from this repository. (Request a copy)Abstract
The timely reconstitution and regain of function of a donor-derived immune system is of utmost importance for the recovery and long-term survival of patients after allogeneic hematopoietic stem cell transplantation (HSCT). Of note, new developments such as umbilical cord blood or haploidentical grafts were associated with prolonged immunodeficiency due to delayed immune reconstitution, raising the need for better understanding and enhancing the process of immune reconstitution and finding strategies to further optimize these transplant procedures. Immune reconstitution post-HSCT occurs in several phases, innate immunity being the first to regain function. The slow T cell reconstitution is regarded as primarily responsible for deleterious infections with latent viruses or fungi, occurrence of graft-versus-host disease, and relapse. Here we aim to summarize the major steps of the adaptive immune reconstitution and will discuss the importance of immune balance in patients after HSCT.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | REGULATORY T-CELLS; VERSUS-HOST-DISEASE; BONE-MARROW-TRANSPLANTATION; CYTOMEGALOVIRUS-SPECIFIC CD4(+); POSTTRANSPLANT LYMPHOPROLIFERATIVE DISEASE; TRANSCRIPTION FACTOR FOXP3; TRANSITIONAL B-CELLS; DONOR LYMPHOCYTES; IDENTIFY PATIENTS; PERIPHERAL-BLOOD; hematopoietic stem cell transplantation; immune reconstitution; infection; graft-versus-leukemia effect; graft-versus-host disease |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 27 Aug 2020 11:56 |
| Last Modified: | 27 Aug 2020 11:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3943 |
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