Schultz, Michael and Schoelmerich, Juergen and Rath, H. C. (2003) Rationale for probiotic and antibiotic treatment strategies in inflammatory bowel diseases. DIGESTIVE DISEASES, 21 (2). pp. 105-128. ISSN 0257-2753
Full text not available from this repository.Abstract
Inflammatory bowel diseases (IBD), commonly referred to as Crohn's disease and ulcerative colitis are chronic aggressive disorders which share many similarities concerning pathomechanism and clinical course, but have very distinct features. Both entities are mainly located in areas with high bacterial concentrations, such as the terminal ileum and cecum in Crohn's disease and the rectum in ulcerative colitis. In recent years, overwhelming evidence accumulated, supporting the hypothesis that IBD are characterized by a genetically determined, overly aggressive immune response towards ubiquitous luminal antigens, especially commensal bacteria and their products. Trials in both human IBD and experimental colitis have demonstrated that broad-spectrum antibiotics may influence the course of ulcerative colitis and Crohn's disease and antibiotics with narrow activity against the anaerobic fraction of the flora can prevent relapse in Crohn's disease after surgically induced remission. Since relevant antibiotic strategies can be associated with some side effects, the ongoing research recently focused on alternative methods to modify the intestinal flora in patients with IBD. Clinical observations including few controlled trials, basic research, and animal studies have suggested a potential role for probiotic bacteria within the treatment regimens for IBD. However, the mode of action of these organisms is still largely unclear and in vitro studies are inconclusive. This review summarizes recent in vitro and in vivo data regarding the role of the intestinal microflora in the pathogenesis of chronic intestinal inflammation and possible therapeutic mechanisms of probiotic bacteria relevant to IBD. Furthermore, we will review clinical trials examining the efficacy of antibiotic and probiotic treatment strategies in IBD. Copyright (C) 2003 S. Karger AG, Basel.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACTIVE CROHNS-DISEASE; GERMINATED BARLEY FOODSTUFF; RANDOMIZED CONTROLLED-TRIAL; HLA-B27 TRANSGENIC RATS; LACTIC-ACID BACTERIA; NONPATHOGENIC ESCHERICHIA-COLI; CLOSTRIDIUM-DIFFICILE COLITIS; LACTOBACILLUS-RHAMNOSUS GG; RESIDENT INTESTINAL FLORA; PLACEBO-CONTROLLED TRIAL; inflammatory bowel disease; antibiotics; probiotics |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 23 Jun 2021 09:10 |
| Last Modified: | 23 Jun 2021 09:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39435 |
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