Kizildere, Selda and Glueck, Thomas and Zietz, Bettina and Schoelmerich, Juergen and Straub, Rainer H. (2003) During a corticotropin-releasing hormone test in healthy subjects, administration of a beta-adrenergic antagonist induced secretion of cortisol and dehydroepiandrosterone sulfate and inhibited secretion of ACTH. EUROPEAN JOURNAL OF ENDOCRINOLOGY, 148 (1). pp. 45-53. ISSN 0804-4643
Full text not available from this repository. (Request a copy)Abstract
Objective: In chronic inflammatory diseases, serum levels of dehydroepiandrosterone (DHEA) sulfate (DHEAS) are low. Interestingly, several non-inflammatory diseases display similarly low levels of DHEAS which points to other inhibitory factors such as an activated sympathetic nervous system (SNS) (e.g. in patients with heart failure, fibromyalgia, or cancer cachexia). We aimed to identify the influence of the SNS tone on stimulated adrenal steroid secretion in 16 male and 12 female healthy subjects. Methods: One group were given oral propranolol 2 h before a corticotropin-releasing hormone (CRII) test, and levels of adrenocorticotropin (ACTH), cortisol, 17-hydroxyprogesterone (17OHP), androstenedione, DHEA, and DHEAS were measured. Results: Propranolol treatment decreased heart rate (by 20%), diastolic blood pressure (by 20%), and plasma ACTH, and increased serum cortisol, serum DHEAS, and the molar ratio of cortisol/17OHP, cortisol/DHEA, and DHEAS/DHEA similarly in female and male subjects. Conclusions: A beta-adrenergic influence seems to decrease CRH-stimulated cortisol in relation to ACTH and 17OHP, and decreases DHEAS in betarelation to DHEA. Although other workers have found beta-adrenergic stimulation of steroid secretion in cultured adrenocortical cells, the overall systemic influence of the SNS via beta-adrenoceptors seems to inhibit adrenal steroids under unstimulated and stimulated conditions. Sympathetic hyperactivity may be a common denominator for low levels of DHEAS in inflammatory and non-inflammatory diseases.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SYSTEMIC-LUPUS-ERYTHEMATOSUS; ZONA-FASCICULATA-RETICULARIS; AUTONOMIC NERVOUS-SYSTEM; BOVINE ADRENAL-CORTEX; RHEUMATOID-ARTHRITIS; ADRENOCORTICAL-CELLS; POSTMENOPAUSAL WOMEN; HYPOGLYCEMIC STRESS; AXIS; CANCER; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Sep 2021 06:38 |
| Last Modified: | 22 Sep 2021 06:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39442 |
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