Fabel, Klaus and Toda, Hiroki and Fabel, Konstanze and Palmer, Theo (2003) Copernican stem cells: Regulatory constellations in adult hippocampal neurogenesis. JOURNAL OF CELLULAR BIOCHEMISTRY, 88 (1). pp. 41-50. ISSN 0730-2312, 1097-4644
Full text not available from this repository. (Request a copy)Abstract
In the adult, neurogenesis occurs where constellations of signaling molecules are correctly orchestrated and where competent cells are present to interpret these signals. As the instruments used to observe adult neurogenesis become more sophisticated, the concept of a discrete competent "stem cell" has become less concrete. Neural progenitor cells once thought committed to a single lineage can be influenced to become multipotent and somatic tissues appear to yield cells capable of tremendous peripheral and central lineage potential. The variety of cell types that appear competent to generate neurons suggests that the "Hilios" of adult neurogenesis may not necessarily be a single cellular entity but rather the sum of signals that dictate, "Make a new neuron here." These signals may not be limited to the recruitment of preexisting neural stem cells but may also, in some subtle way, reprogram local precursors to create "stem-like cells," where needed. (C) 2002 Wiley-Liss, Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CENTRAL-NERVOUS-SYSTEM; FIBROBLAST GROWTH FACTOR-2; DENTATE GYRUS; RAT HIPPOCAMPUS; FACTOR GENE; FACTOR-I; BRAIN; NEURONS; ASTROCYTES; NEOCORTEX; neurogenesis; stem cell; adult; hippocampus; progenitor; precursor; microenvironment; signaling |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Sep 2021 12:54 |
| Last Modified: | 22 Sep 2021 12:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39474 |
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