Stanewsky, Ralf (2003) Genetic analysis of the circadian system in Drosophila melanogaster and mammals. JOURNAL OF NEUROBIOLOGY, 54 (1). pp. 111-147. ISSN 0022-3034
Full text not available from this repository. (Request a copy)Abstract
The fruit fly, Drosophila melanogaster, has been a grateful object for circadian rhythm researchers over several decades. Behavioral, genetic, and molecular studies helped to reveal the genetic bases of circadian time keeping and rhythmic behaviors. Contrary, mammalian rhythm research until recently was mainly restricted to descriptive and physiologic approaches. As in many other areas of research, the surprising similarity of basic biologic principles between the little fly and our own species, boosted the progress of unraveling the genetic foundation of mammalian clock mechanisms. Once more, not only the basic mechanisms, but also the molecules involved in establishing our circadian system are taken or adapted from the fly. This review will try to give a comparative overview about the two systems, highlighting similarities as well as specifics of both insect and murine clocks. (C) 2003 Wiley Periodicals, Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | KINASE-I-EPSILON; SLEEP-PHASE SYNDROME; MOUSE SUPRACHIASMATIC NUCLEUS; RNA-BINDING PROTEIN; PER-TIM COMPLEX; CLOCK GENE; BIOLOGICAL CLOCK; MESSENGER-RNA; TRANSCRIPTION FACTOR; BEHAVIORAL RHYTHMS; Drosophila melanogaster; circadian time deeping; genetic analysis |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Entwicklungsbiologie (Prof. Dr. Stephan Schneuwly) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 23 Jun 2021 09:03 |
| Last Modified: | 23 Jun 2021 09:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39478 |
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