Bedoui, Sammy and Kawamura, Noriyuki and Straub, Rainer H. and Pabst, Reinhard and Yamamura, Takashi and von Hoersten, Stephan (2003) Relevance of Neuropeptide Y for the neuroimmune crosstalk. JOURNAL OF NEUROIMMUNOLOGY, 134 (1-2). pp. 1-11. ISSN 0165-5728, 1872-8421
Full text not available from this repository. (Request a copy)Abstract
Both cellular and humoral functions of the immune system are modulated by the sympathetic nervous system (SNS). This interaction is mainly mediated by the release of catecholamines (CA) and their receptor-specific action on immune cells. However, neuropeptide Y (NPY), also present in sympathetic nerve terminals, is released upon SNS-stimulation. NPY modulates potent immunological effects in vitro and in vivo, such as differentiation of T helper cells, monocyte mediator release, NK cell activation, and immune call redistribution. In addition to this direct action within the neuroimmune crosstalk, NPY is also able to modulate the immunomodulatory effects of other neurotransmitters, thereby acting as a neuroimmune co-transmitter. This review will discuss key findings from recent studies, provide implications for the clinical situation, and integrate the pleiotropic functions of NPY in the context of neuroimmune interactions. (C) 2002 Elsevier Science B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENE-RELATED PEPTIDE; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; VASOACTIVE INTESTINAL POLYPEPTIDE; TEMPOROMANDIBULAR-JOINT ARTHRITIS; PERITONEAL MACROPHAGE FUNCTIONS; GASTRIN-RELEASING PEPTIDE; AUTONOMIC NERVOUS-SYSTEM; BETA-ADRENERGIC AGONISTS; NATURAL-KILLER ACTIVITY; NECROSIS-FACTOR-ALPHA; neuropeptide Y; immune functions; leukocytes; co-transmission; autoinummity; infection |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 23 Jun 2021 09:06 |
| Last Modified: | 23 Jun 2021 09:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39479 |
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