Botella, José A. and Kretzschmar, Doris and Kiermayer, Claudia and Feldmann, Pascale and Hughes, David A. and Schneuwly, Stephan (2003) Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap. MOLECULAR BIOLOGY OF THE CELL, 14 (1). pp. 241-250. ISSN 1059-1524
Full text not available from this repository.Abstract
Ras signaling has been shown to play an important role in promoting cell survival in many different tissues. Here we show that upregulation of Ras activity in adult Drosophila neurons induces neuronal cell death, as evident from the phenotype of vacuolar peduncle (vap) mutants defective in the Drosophila RasGAP gene, which encodes a Ras GTPase-activating protein. These mutants show age-related brain degeneration that is dependent on activation of the EGF receptor signaling pathway in adult neurons, leading to autophagic cell death (cell death type 2). These results provide the first evidence for a requirement of Egf receptor activity in differentiated adult Drosophila neurons and show that a delicate balance of Ras activity is essential for the survival of adult neurons.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GTPASE-ACTIVATING PROTEIN; PROGRAMMED CELL-DEATH; GUANINE-NUCLEOTIDE EXCHANGE; RECEPTOR TYROSINE KINASE; EGF RECEPTOR; LAMINA GANGLIONARIS; ADAPTER PROTEIN; NERVOUS-SYSTEM; GROWTH-FACTOR; RAS; |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Entwicklungsbiologie (Prof. Dr. Stephan Schneuwly) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Aug 2021 09:46 |
| Last Modified: | 26 Aug 2021 09:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39501 |
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