Bux, J. and Cassens, U. and Dielschneider, T. and Duchscherer, M. and Edel, E. and Eichler, H. and Haas, C. and Moog, R. and Peschke, H. and Peters, C. and Ryzenkov, I. and Schlenke, P. and Ullrich, H. and Wiesneth, M. (2003) Tolerance of granulocyte donors towards granulocyte colony-stimulating factor stimulation and of patients towards granulocyte transfusions: results of a multicentre study. VOX SANGUINIS, 85 (4). pp. 322-325. ISSN 0042-9007
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Data of 507 granulocyte donations from 183 donors were evaluated. No severe granulocyte colony-stimulating factor (G-CSF)-related side-effects were observed. Three donors complained of severe itching following infusion of hydroxyethyl starch (HES). A high proportion (85%) of the donors stated that they would donate granulocytes again. The mean granulocyte yield was 4.3 x 10(10). High-molecular-weight HES resulted in a significantly higher yield compared with low-molecular-weight HES. Mild, but no severe, adverse transfusion reactions were observed in 16% of the recipients. A leucocyte alloimmunization rate of 24% was found. G-CSF stimulation and transfusion of G-CSF-mobilized granulocytes were well tolerated by donors and recipients, respectively
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STEM-CELL TRANSPLANTATION; EFFICACY; CSF; METAANALYSIS; INFECTIONS; SEPSIS; granulocyte transfusion; G-G'SF; granulocyte apheresis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Aug 2021 11:04 |
| Last Modified: | 05 Aug 2021 11:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39547 |
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