Haerle, Peter and Cutolo, Maurizio and Schoelmerich, Juergen and Straub, Rainer H. (2002) Rheumatoid arthritis - Pathogenetic role of neuroendocrine axes and the peripheral nervous system. MEDIZINISCHE KLINIK, 97 (12). pp. 720-729. ISSN 0723-5003, 1615-6722
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Background: Local innate and adaptive immune processes are of importance during the acute phase of rheumatoid arthritis (RA). In the advanced inflammatory phase alterations of systemic anti-inflammatory feedback mechanisms might be important features which may support chronic inflammation. Alterations: Similarly, like in other chronic inflammatory diseases, inadequately low cortisol and androgen serum levels can be detected in RA patients. In addition, there is a marked reduction of anti-inflammatory sympathetic nerve fibers in the inflamed joints paralleled by an enhanced number of pro-inflammatory sensory nerve fibers. Thus, an uncoupling of synergistically acting endocrine and neuronal, anti-inflammatory mechanisms (cortisol, dehydroepiandrosterone, androgens, sympathetic neurotransmitters) and a preponderance of pro-inflammatory mechanisms (estrogens, sensory neurotransmitters) may lead to chronic inflammatory disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PITUITARY-ADRENAL AXIS; BLOOD MONONUCLEAR-CELLS; TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; COLLAGEN-INDUCED ARTHRITIS; GENE-RELATED PEPTIDE; LUPUS-ERYTHEMATOSUS; SUBSTANCE-P; SYNOVIAL TISSUE; ADRENOCORTICOTROPIC HORMONE; rheumatoid arthritis; synovium; norepinephrine; substance P; androgens; estrogens; therapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 23 Jun 2021 06:47 |
| Last Modified: | 23 Jun 2021 06:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39564 |
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