Diep, Quy N. and Amiri, Farhad and Touyz, Rhian M. and Cohn, Jeffrey S. and Endemann, Dierk and Neves, Mario Fritsch and Schiffrin, EL (2002) PPAR alpha activator effects on Ang II-induced vascular oxidative stress and inflammation. HYPERTENSION, 40 (6). pp. 866-871. ISSN 0194-911X
Full text not available from this repository. (Request a copy)Abstract
Docosahexaenoic acid (DHA), a peroxisome proliferator-activated receptor-alpha (PPARalpha) activator, reduces blood pressure (BP) in some hypertensive models by unclear mechanisms. We tested the hypothesis that DHA would prevent BP elevation and improve vascular dysfunction in angiotensin (Ang) II-infused rats by modulating of NADPH oxidase activity and inflammation in vascular wall. Sprague-Dawley rats received Ang II (120 ng/kg per-minute SC) with or without DHA (2.5 mL of oil containing 40% DHA/d PO) for 7 days. Systolic BP (mm Hg), elevated in Ang II-infused rats (172+/-3) versus controls (108+/-2, P<0.01), was reduced by DHA (112+/-4). In mesenteric small arteries studied in a pressurized myograph, media/lumen ratio was increased (P<0.05) and acetylcholine-induced relaxation impaired in Ang II-infused rats (P<0.05); both were normalized by DHA. In blood vessels of Ang II-infused rats, NADPH oxidase activity measured by chemiluminescence and expression of adhesion molecules intercellular adhesion molecule and vascular cell adhesion molecule-1 were significantly increased. These changes were abrogated by DHA. PPARa activator DHA attenuated the development of hypertension, corrected structural abnormalities, and improved endothelial dysfunction induced by Ang II. These effects are associated with decreased oxidative stress and inflammation in the vascular wall.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SMOOTH-MUSCLE CELLS; SPONTANEOUSLY HYPERTENSIVE RATS; LOW-DENSITY-LIPOPROTEIN; DOCOSAHEXAENOIC ACID; RECEPTOR-ALPHA; KAPPA-B; EICOSAPENTAENOIC ACID; ADHESION MOLECULE-1; ENDOTHELIAL-CELLS; BLOOD-PRESSURE; hypertension, experimental; resistance; remodeling; muscle, smooth, vascular; free radicals |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Mar 2022 07:57 |
| Last Modified: | 21 Mar 2022 07:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39605 |
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