Hoecherl, Klaus and Dreher, Franziska and Kurtz, Armin and Bucher, Michael (2002) Cyclooxygenase-2 inhibition attenuates lipopolysaccharide-induced cardiovascular failure. HYPERTENSION, 40 (6). pp. 947-953. ISSN 0194-911X
Full text not available from this repository. (Request a copy)Abstract
The present study aimed to determine the relevance of cyclooxygenase-2 (COX-2)-derived prostanoids for the adverse effects of lipopolysaccharides (LPSs) on cardiovascular function. For this goal, mate Sprague-Dawley rats received a single intravenous dose of LPS (10 mg/kg) and were treated with different cyclooxygenase inhibitors. Injection of LPS caused a marked decrease of systolic arterial pressure, from 128 to 79 mm Hg, and a concomitant increase of heart rate, from 380 to 530 minutes(-1). Both the decrease of systemic arterial pressure and the increase of heart rate induced by LPS were almost absent if the animals also received the COX-2 blocker rofecoxib (20 mg/kg), regardless whether the drug was given 1 hour before or 1. hour after LPS. Although plasma and organ levels of prostanoids were lowered by rofecoxib, the characteristic LPS-induced increases of NO synthase II and COX-2 gene expression, as well as of plasma and tissue nitrate/nitrite concentrations, were not affected by rofecoxib. Although rofecoxib treatment did also not change LPS-induced tissue cytokine concentrations, it markedly improved LPS-induced liver damage, as indicated by the decrease of transaminases. Moreover, the overall well-being of the LPS-injected animals improved on concomitant treatment with the COX-2 inhibitor. Taken together, our data suggest that COX-2-derived prostanoids are major mediators for the detrimental effects of LPS on cardiovascular and organ function.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NITRIC-OXIDE SYNTHASE; SEVERE SEPTIC SHOCK; SELECTIVE INHIBITOR; ENDOTOXIC-SHOCK; RAT MODEL; CIRCULATORY FAILURE; L-CANAVANINE; IN-VIVO; SEPSIS; SURVIVAL; shock; cyclooxygenase; hemodynamics; prostaglandins; nitric oxide |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine 600 Technology > 615 Pharmacy |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Sep 2021 10:41 |
| Last Modified: | 28 Sep 2021 10:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39606 |
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