Lazewska, Dorota and Kiec-Kononowicz, Katarzyna and Pertz, H. H. and Elz, Sigurd and Stark, Holger and Schunack, W. (2002) Piperidine-containing histamine H-3 receptor antagonists of the carbamate series: the influence of the additional ether functionality. PHARMAZIE, 57 (12). pp. 791-795. ISSN 0031-7144
Full text not available from this repository. (Request a copy)Abstract
Recently novel leads for histamine H-3 receptor antagonists of the non-imidazole type have been described. As a continuation of this research eleven new carbamate derivatives possessing an additional ether functionality were prepared. The compounds were evaluated in vitro for their antagonist activity on isolated organs of guinea-pig (GP) H-3 as well as H-2, H-1, and M-3 receptors, respectively. All compounds investigated possessed moderate antagonist affinities at guinea-pig histamine H-3 receptors (pA(2) 6.11-6.76). An ether functionality introduced in different places of the lipophilic part of carbamates differently influenced activity and selectivity toward H-3, M-3, and other histamine receptors tested.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PRESYNAPTIC H-3-RECEPTORS; AMINO-ACIDS; CLONING; EXPRESSION; RELEASE; POTENT; BRAIN; RAT; |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Sep 2021 04:58 |
| Last Modified: | 29 Sep 2021 04:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39639 |
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