Schroeppel, Bernd and Fischereder, Michael and Lin, Marvin and Marder, Brad and Schiano, Tom and Kraemer, Bernhard K. and Murphy, Barbara (2002) Analysis of gene Polymorphisms in the regulatory region of MCP-1, RANTES, and CCR5 in liver transplant recipients. JOURNAL OF CLINICAL IMMUNOLOGY, 22 (6). pp. 381-385. ISSN 0271-9142
Full text not available from this repository. (Request a copy)Abstract
Chemokines and their receptors play a major role in the inflammatory and immune responses that mediate allograft outcome. The production of some chemokines varies among individuals and these variations may be determined by genetic polymorphisms, most commonly within the regulatory region of the gene. We investigated whether the functional polymorphisms of the chemokines RANTES, MCP-1 and chemokine receptor CCR5 are associated with the incidence of acute rejection and long-term liver graft survival. Two hundred nine liver transplant recipients were genotyped using polymerase chain reaction sequence-specific primers for the following polymorphisms: RANTES-28, MCP-1 -2518, and CCR5-59029. There was no association with any of the three genotypes and the incidence of acute rejection episodes. In addition, no association of RANTES-28, MCP-1 -2518, or CCR5-59029 variants with long-term liver graft survival was found. In conclusion, variants of RANTES-28, MCP-1 -2518, and CCR5-59029 neither influenced the incidence of acute rejection nor affected long-term allograft survival upon liver transplantation in the context of this analysis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HIV-1 DISEASE PROGRESSION; CHEMOKINE RECEPTORS; EXPRESSION; REJECTION; PROMOTER; liver transplantation; graft survival; rejection; MCP-1; RANTES; CCR5 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Oct 2021 05:33 |
| Last Modified: | 04 Oct 2021 05:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39734 |
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