Bedoui, Sammy and Lechner, Sandra and Gebhardt, Thomas and Nave, Heike and Beck-Sickinger, Annette G. and Straub, Rainer H. and Pabst, Reinhard and von Hoersten, Stephan (2002) NPY modulates epinephrine-induced leukocytosis via Y-1 and Y-5 receptor activation in vivo: sympathetic co-transmission during leukocyte mobilization. JOURNAL OF NEUROIMMUNOLOGY, 132 (1-2): PII S0165-. pp. 25-33. ISSN 0165-5728
Full text not available from this repository. (Request a copy)Abstract
Sympathetic nervous system (SNS) activation mobilizes blood leukocytes. Under these circumstances, both epinephrine (EPI) and neuropeptide Y (NPY) are released. Therefore, we investigated a possible interaction between these transmitters during leukocyte mobilization, using intravenous catheterization of male adult Lewis rats. Intravenous application of NPY followed by EPI, dose-dependently facilitated, intensified and inhibited EPI-induced leukocytosis with subset-specificity for NK-cells, monocytes, and B-lymphocytes. Pharmacological assessment of NPY receptors involved revealed a Y-1R-mediated inhibition and a Y-5R-mediated facilitation. RT-PCR on peripheral blood mononuclear cells (PBMC) detected Y-1R mRNA only, suggesting direct Y-1R-mediated effects on leukocytes and indirect effects via the Y-5R. Thus, via a specific Y-1R/Y-5R interplay, NPY acts as a neuroimmune co-transmitter in vivo. (C) 2002 Elsevier Science B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NEUROPEPTIDE-Y; IMMUNE-SYSTEM; DYNAMIC EXERCISE; NERVE; NORADRENALINE; RATS; NOREPINEPHRINE; LYMPHOCYTES; AGONIST; PROTEIN; neuropeptide Y; epinephrine; co-transmission; leukocytosis; male lewis rats; in vivo catheterization |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Oct 2021 05:56 |
| Last Modified: | 04 Oct 2021 05:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39738 |
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