Stratz, T. and Faerber, L. and Mueller, Wolfgang (2002) Local treatment of tendinopathies: a comparison between tropisetron and depot corticosteroids combined with local anesthetics. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 31 (6). pp. 366-369. ISSN 0300-9742
Full text not available from this repository. (Request a copy)Abstract
Objective: To determine whether local injection of the 5-HT3-receptor antagonist, tropisetron, reduces pain in tendinopathies to the same degree as a local injection of corticosteroids in combination with local anesthetic. Methods: Forty patients with tendinopathies were enrolled in this randomized, observer-blind study. An injection of either 5 mg tropisetron, or 10 mg dexamethasone combined with 60 mg lidocaine was administered around the affected tendon. The effect was measured with a visual analog pain scale before the injection, after 3 hours and on each of the following 7 days, in patients with good effects also 3 months after the injection. Results: There were no significant differences between the tropisetron and the corticosteroid/anesthetic group in terms of pain at rest or on movement during the study. Both treatments were well tolerated. Conclusion: Local injection of tropisetron seems to be as safe and as effective as the combination of corticosteroids and local anesthetics in the treatment of painful tendinopathies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 5-HT3 RECEPTOR ANTAGONISTS; ADMINISTERED SEROTONIN; DOUBLE-BLIND; FIBROMYALGIA; INJECTION; PAIN; SHOULDER; RAT; tendinopathy; therapy; 5-HT3 receptor antagonists; corticosteroids; local anesthetic |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Oct 2021 06:51 |
| Last Modified: | 04 Oct 2021 06:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39761 |
Actions (login required)
 |
View Item |
