Schmitz, Gerd and Orso, Evelyn (2002) CD14 signalling in lipid rafts: new ligands and co-receptors. CURRENT OPINION IN LIPIDOLOGY, 13 (5). pp. 513-521. ISSN 0957-9672
Full text not available from this repository.Abstract
Purpose of review Lipid rafts on monocytes/macrophages provide a dynamic microenvironment for an integrated lipopolysaccharide receptor (CD14)-dependent clustering of a set of receptors involved in innate immunity and clearance of atherogenic lipoproteins. The purpose of this review is to summarize the recent advances in our understanding of CD14-dependent receptor clustering and its relevance in atherogenesis. Recent findings Upon binding of various ligands, CD14 as a multiligand pattern recognition receptor induces specific coassembly of additional receptors present on circulating monocytes. Summary The composition of the receptor cluster and thus the associated signalling pathways defines a ligand specific cellular response, linking endogenous and exogenous host defense to a common recognition platform in rafts.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TOLL-LIKE RECEPTOR-4; LIPOPOLYSACCHARIDE-BINDING-PROTEIN; CELL-WALL COMPONENTS; PLASMA-MEMBRANE; HUMAN MONOCYTES; GENE-EXPRESSION; LPS; TLR4; MUTATIONS; ATHEROGENESIS; CD14-dependent receptor cluster; raft-heterogeneity; LPS-mediated signalling; atherogenesis; innate immunity; mononuclear phagocytes |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Petra Gürster |
| Date Deposited: | 09 Jun 2021 10:08 |
| Last Modified: | 09 Jun 2021 10:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39809 |
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