Requirement for tumor necrosis factor receptor 2 expression on vascular cells to induce experimental cerebral malaria

Stoelcker, Benjamin and Hehlgans, Thomas and Weigl, Karin and Bluethmann, Horst and Grau, Goerges E. and Maennel, Daniela N. (2002) Requirement for tumor necrosis factor receptor 2 expression on vascular cells to induce experimental cerebral malaria. INFECTION AND IMMUNITY, 70 (10). pp. 5857-5859. ISSN 0019-9567

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Abstract

Using tumor necrosis factor receptor type 2 (TNFR2) -deficient mice and generating bone marrow chimeras which express TNFR2 on either hematopoietic or nonhematopoietic cells, we demonstrated the requirement for TNFR2 expression on tissue cells to induce lethal cerebral malaria. Thus, TNFR2 on the brain vasculature mediates tumor necrosis factor-induced neurovascular lesions in experimental cerebral malaria.

Item Type: Article
Uncontrolled Keywords: NF-KAPPA-B; MOUSE MODEL; TNF; ANTIBODY; MICE;
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Pathologie
Depositing User: Dr. Gernot Deinzer
Date Deposited: 05 Oct 2021 05:21
Last Modified: 05 Oct 2021 05:21
URI: https://pred.uni-regensburg.de/id/eprint/39828

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