Krueger, Bernd and Schroeppel, Bernd and Ashkan, Rami and Marder, Brad and Zuelke, Carl and Murphy, Barbara and Kraemer, Bernhard K. and Fischereder, Michael (2002) A monocyte chemoattractant protein-1 (MCP-1) polymorphism and outcome after renal transplantation. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 13 (10). pp. 2585-2589. ISSN 1046-6673
Full text not available from this repository. (Request a copy)Abstract
Among the factors modulating transplant rejection and cardiovascular disease, chemokines and their respective receptors deserve special attention. In this respect, increased expression of MCP-1 and the corresponding receptor CCR2 have been demonstrated in renal transplant rejection and coronary artery disease. The impact of the MCP-1-2518G and CCR2-64I genotypes on renal allograft function was investigated in 232 patients who underwent transplantation over an 11-yr period. Genomic DNA was genotyped using PCR with sequence-specific primers followed by restriction fragment length polymorphism analysis. Eighteen (7.8%) patients were homozygous for the MCP-1-2518G mutation. The G/G allele of MCP-1 -2518 behaved as a determinant for long-term allograft survival and resulted in reduction of the mean graft survival, as compared with the heterozygous (A/G) or wild-type (A/A) allele (67 +/- 14 versus 95 +/- 4 mo; Log rank P = 0.0052). The 641 mutation of CCR2 had no effect on kidney graft failure (93 +/- 6 and 91 +/- 5 mo, respectively; P = 0.81). None of the investigated polymorphisms showed a significant shift in gene frequency in acute rejection and rejection-free groups. In conjunction with these findings, peripheral blood mononuclear cells from kidney transplant recipients carrying the G-allele were characterized by a 2.5-fold higher MCP-1 secretion (P < 0.05). In conclusion, recipients of renal transplants homozygous for the -2518 G mutation of the MCP-1 gene are at risk for premature kidney graft failure. This variant of MCP-1 may be a future predictor for long-term kidney graft failure.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ALLOGRAFT-REJECTION; REDUCES ATHEROSCLEROSIS; CHEMOKINE RECEPTORS; DEFICIENT MICE; EXPRESSION; INVOLVEMENT; SURVIVAL; ABSENCE; RANTES; RATS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Oct 2021 06:37 |
| Last Modified: | 05 Oct 2021 06:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39843 |
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