Cooper-Kuhn, Christiana M. and Vroemen, Maurice and Brown, Jason and Ye, Hong and Thompson, Margaret A. and Winkler, Juergen and Kuhn, H. Georg (2002) Impaired adult neurogenesis in mice lacking the transcription factor E2F1. MOLECULAR AND CELLULAR NEUROSCIENCE, 21 (2). pp. 312-323. ISSN 1044-7431
Full text not available from this repository. (Request a copy)Abstract
During nervous system development the fate of neural stem cells-whether to undergo proliferation, differentiation, or apoptosis-is controlled by various signals, such as growth factors. Here, we demonstrate that the transcription factor E2F1, which is targeted by several signaling cascades that are activated by growth factors, is involved in neurogenesis in the adult brain. When analyzing the brains of E2F1-deficient mice, we found significantly decreased stem cell and progenitor division in the proliferative zones of the lateral ventricle wall and the hippocampus. As a consequence, the production of newborn neurons in the adult olfactory bulb and dentate gyrus was decreased. Neuronal cell counts of the adult cerebellum revealed a mild but significant cerebellar atrophy, whereas neocortical neurons were unaffected, suggesting that E2F1 deficiency produces a predominantly postnatal phenotype. The results indicate an involvement of E2F1 in controlling proliferation and neuronal cell numbers in the postnatal and adult brain.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | S-PHASE ENTRY; NEURAL STEM-CELLS; DENTATE GYRUS; ALZHEIMERS-DISEASE; OLFACTORY-BULB; RAT BRAIN; APOPTOSIS; NEURONS; DIFFERENTIATION; PROLIFERATION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Oct 2021 06:47 |
| Last Modified: | 05 Oct 2021 06:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39846 |
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