Trabold, Benedikt and Rzepecki, Angela and Sauer, Kay and Hobbhahn, Jonny (2002) A comparison of two different doses of ketamine with midazolam and midazolam alone as oral preanaesthetic medication on recovery after sevoflurane anaesthesia in children. PAEDIATRIC ANAESTHESIA, 12 (8). pp. 690-693. ISSN 1155-5645
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Background: This investigation prospectively evaluated the effect of oral premedication of two different doses of ketamine with midazolam and midazolam alone on the recovery of children after sevoflurane anaesthesia. Methods: In a randomized, double-blind study, 79 children (aged 1-8 years, ASA physical status I or II) were assigned to receive one of three premedications in a volume of 0.5 ml.kg(-1) : group 1 received midazolam 0.5 mg.kg(-1) (MD); group 2 received midazolam 0.5 mg.kg(-1) with ketamine 1.8 mg.kg(-1) (MK-1); and group 3 received midazolam 0.5 mg.kg(-1) with ketamine 3 mg.kg(-1) (MK-2). The reactions of the children during administration were noted. Anaesthesia was induced by facemask with incremental sevoflurane administration. All children received alfentanil (15 mug.kg(-1)). Tracheal intubation was facilitated by mivacurium (0.2 mg.kg(-1)). Anaesthesia was maintained with sevoflurane and an additional dose of alfentanil, if necessary. During recovery, the time interval between discontinuation of anaesthesia and arousal (spontaneous ventilation, extubation) were recorded. Results: Emergence (spontaneous ventilation, extubation) and recovery times (discharge, Aldrete score = 9) did not differ significantly between groups (P = 0.24, P = 0.59 and P = 0.145, respectively). Conclusions : The combination of midazolam and ketamine as oral preanaesthetic medication did not significantly affect the recovery time of children after sevoflurane anaesthesia.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PREMEDICATION DELAYS RECOVERY; ANESTHESIA; COMBINATION; PROPOFOL; TIME; anaesthesia; premedication : midazolam; ketamine; recovery |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Oct 2021 08:06 |
| Last Modified: | 05 Oct 2021 08:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39851 |
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